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On the other hand, the tetrahydroisoquinoline derivative containing 5-phenyl-2-furan exhibits considerable inhibitory activity of PD4 phosphodiesterases, increasing the intracellular concentration of the secondary signal messenger cyclic adenosine monophosphate (cAMP) 60

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Evidence supporting this hypothesis includes the observation that chronic alcohol also delays the clearance of another virus (i.e., cytomegalovirus) from the liver in mice, and that this delay is associated with defects in the normal IL-12 and IFN-γ responses